裴海闰
裴海闰
性别：男
系别：生物工程系
职称：副教授
导师类型：硕导
学历学位：博士
Email：phr1211@163.com
社会兼职：中国抗衰老促进会教育培训工作委员会专家委员，Journal of Future Foods青年编委。
个人简历
教育经历：
2013-09至2018-01, 北京师范大学，化学学院，博士
2007-09至2010-07，北京工商大学，化学与环境工程学院，生物化工，硕士
2003-09至2007-07，北京工商大学，化学与环境工程学院，生物工程，学士
工作经历：
2010-08至现在，北京工商大学，英国威廉希尔公司，生物工程系，副教授
2025-05至2025-12，Queen’s University，访问学者
主讲课程
本科生：生物分离工程，生物工程设备，生物工厂设计及项目管理
研究生：现代生物分离技术，文献管理与数据处理
主要研究领域
高速逆流色谱在天然产物分离提取中的应用，蛋白质和多糖等生物大分子的结构与功能研究。
主要学术成果（课题、论文、获奖、专利等）
科研项目：
(1) 国家科技部，重点研发计划项目课题，2018YFC1604306，乳制品中香精和色素等添加剂的安全性研究及风险评价体系构建，2018-12至2021-11，403万元/127万元，结题，课题参加。
(2) 国家自然科学基金面上项目基金项目，21773014，Cpx信号系统中YihE蛋白激酶与Rho转录终止因子相互作用及调控机理研究，2018/01-2021/12，64万元，结题，参加
(3)北京市基金-市教委联合资助科技重点项目，KZ202010011017，绿色低粘度天然深共熔溶剂体系的设计及其在逆流色谱分离中的应用，2020/01-2022/12，结题，参加；
学术论文：
(1) Ruiling Zhang†, Meiling Zhang†, Xiaoyu Li†, Zhifang Lu, Chen Song, Yangchun Du, Chelsy Chesterman, Laura van Staalduinen, Youjun Wang, Hairun Pei*, Zongchao Jia*, Jimin Zheng*. (2025), A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity. International Journal of Biological Macromolecules, 332, 148613.
(2) Yan Pan†, Jimin Zheng†, Zhixuan Wang, Shaohua Lin, Hongliang Jia, Hairun Pei*, Ronghui Ju*. (2025), Quinoa and Colonic Health: A Review of Bioactive Components and Mechanistic Insights. Current Issues in Molecular Biology. 2025, 47, 815
(3) Hairun Pei, Kaiyue Bao, Tian Han* & Xueli Cao*. (2025), Comprehensive insights into microbial-derived antimicrobial peptides (AMPs): classification, mechanisms, applications, and purification strategies. Critical Reviews in Biotechnology, 45(8), 1652-1679.
(4) Hitache Zeyneb†, Ya Song†, Lin Wang, Jimin Zheng, Wei Wang, Hairun Pei*, Xueli Cao*. (2025), Preventive effect of quinoa polysaccharides on lipopolysaccharide-induced inflammation in mice through gut microbiota regulation. International Journal of Biological Macromolecules, 307, 141899.
(5) Hairun Pei, Kaiyue Bao, Yiheng Ye, Ya Song, Ping Liu, Yingyi Han*, Xueli Cao*. (2025), Development of a ready-to-use astaxanthin esters extract from Haematococcus pluvialis using hydrophobic NADES: Optimization, mechanistic insights, and stability evaluation, Microchemical Journal, 209,112794.
(6) Ping Liu, Lin Wang, Ya Song, Hairun Pei*, and Xueli Cao*. (2024), Virtual Screening of Inhibitors of Streptococcus mutans Biofilm from Lonicera japonica flos and Activity Validation. ACS Medicinal Chemistry Letters, 15(6), 781-790
(7) Lin Wang, Xueli Cao*, Hairun Pei*, Ping Liu, Ya Song, Yulun Wu. (2023), Anti-Biofilm Activity of Chlorogenic Acid against Pseudomonas Using Quorum Sensing System. Foods, 12(19), 3601.
(8) Zeyneb Hitache, Sam Al-Dalali, Hairun Pei*, Xueli Cao*. (2023), Review of the Health Benefits of Cereals and Pseudocereals on Human Gut Microbiota. Food and Bioprocess Technology, 16 (11), 2382-2399.
(9) Yiheng Ye; Hairun Pei*; Xueli Cao*; Xueying Liu; Zhanghan Li; Biying Wang; Yan Pan; and Jimin Zheng. (2023), The Study of a Novel Paeoniflorin-Converting Enzyme from Cunninghamella blakesleeana. Molecules, 28 (3):1289.
(10) Biying Wang†, Hairun Pei†(共同一作), Zhifang Lu, Yingying Xu, Shengnan Han, Zongchao Jia*, Jimin Zheng*. (2022), YihE is a novel binding partner of Rho and regulates Rho-dependent transcription termination in the Cpx stress response. iScience, 25(12): 105483
(11) Hitache Zeyneb, Hairun Pei*, Xueli Cao*, Yuxin Wang, Yumon Win, Lingxiao Gong. (2021), In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota. Food Science & Nutrition, 9(10), 5735– 5745.
(12) Yan Pan, Ronghui Ju, Xueli Cao*, Hairun Pei*, Tianhao Zheng, Wei Wang. (2020), Optimization extraction and purification of biological activity curcumin from Curcuma longa L by high-performance counter-current chromatography. J Sep Sci, 43(8): 1586-1592.
(13) Hairun Pei, Xiaotong Ma, Yan Pan, Tian Han, Zhifang Lu, Ruijuan Wu, Xueli Cao*, Jimin Zheng*. (2019), Separation and purification of lanosterol, dihydrolanosterol, and cholesterol from lanolin by high-performance counter-current chromatography dual-mode elution method. J Sep Sci, 42:2171–2178.
(14) Hairun Pei, Shengnan Han, Shaoyuan Yang, Zhen Lei, Jimin Zheng*, Zongchao Jia*. (2017), Phosphorylation of bacterial L9 and its function implication in response to starvation stress. FEBS Letters, 591(20): 3421~3430.
(15)韩潆仪,李章涵,曹学丽*,裴海闰*. 芍药苷转化酶G6046的异源表达及酶活鉴定. 生物技术通报. 2023, (12): 200-208;
(16) 马晓彤, 刘曼, 裴海闰*, 曹学丽*. 新型离子液体亲和萃取鸡蛋清中的溶菌酶. 食品工业科技, 2018, (21): 35-40+47.
(17) 裴海闰，曹学丽*. 圆盘嵌入式螺旋管高速逆流色谱仪及其在花青素分离中的应用. 食品科学, 2012，33（11）:1-7.
(18)裴海闰（2/6）, 基于逆流色谱的天然活性物质新型分离系统及分离方法研究，北京市人民政府，北京市科学技术奖，一等奖，2012（曹学丽，裴海闰，霍亮生，胡光辉，徐春明，任虹）